Yulia D. Ivanova, Mikhail V. Maltsev, Alexander V. Kuzubov, Natalya A. Mohamed-Amin MODELLING OF CHRONIC STRESS IN MALE RATS SUBJECTED TO PROLONGED ISOLATION

DOI: https://doi.org/10.15688/nsr.jvolsu.2021.1.2

Yulia D. Ivanova, Master Student, Department of Biology, Volgograd State University, Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation, This email address is being protected from spambots. You need JavaScript enabled to view it.
Mikhail V. Maltsev, Сandidate of Sciences (Biology), Associate Professor, Department of Biology, Volgograd State University, Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation,  This email address is being protected from spambots. You need JavaScript enabled to view it.  
Alexander V. Kuzubov, Candidate for a Degree, Toxicology Laboratory, Scientific Center for Innovative Medicines with Pilot Production, Volgograd State Medical University, Novorossiyskaya St, 39, 400087 Volgograd, Russian Federation, This email address is being protected from spambots. You need JavaScript enabled to view it.
Natalya A. Mohamed-Amin, Candidate of Sciences (Medicine), Senior Lecturer, Department of Biology, Volgograd State Medical University, Rokossovskogo St, 1G, 400131 Volgograd, Russian Federation,  This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract. Artificially created social isolation in rodents models a form of chronic stress that causes neurodegenerative changes in the brain and subsequent behavioral changes. The aim of this study was to simulate chronic stress in male rats by social isolation and to determine how chronic stress affects the behavioral and sexual responses of rats. During the simulation of chronic stress, rats were divided into two groups: experimental one, where laboratory animals were kept in separate cells for 10 weeks, and control one, where laboratory animals were kept under normal conditions. Subsequently, a clinical examination of each rat, behavioral tests (“Open Field”, “Forced Swimming of Porsolt”, “Raised Cruciate Maze”) and a study of male sexual behavior were carried out to detect changes in behavioral and sexual responses of the animals. The obtained results of behavioral tests and sexual behavior claim marked changes in behavioral and sexual reactions in the experimental group of animals (high emotional reactivity, reduced orientation and research reactions, high sexual activity and increased aggression against females). Thus, the authors conclude on successful modelling of chronic stress through social isolation. This model can be used at the deeper study and development of methods of neuropsychiatric disorders therapy.

Key words: social isolation, behavioral tests, sexual behavior, chronic stress, rats, modelling.

Citation. Ivanova Yu.D., Maltsev M.V., Kuzubov A.V., Mohamed-Amin N.A. Modelling of Chronic Stress in Male Rats Subjected to Prolonged Isolation. Prirodnye sistemy i resursy [Natural Systems and Resources], 2021, vol. 11, no. 1, pp. 12-19. DOI: https://doi.org/10.15688/nsr.jvolsu.2021.1.2

Horse Ammunition. From the History of a Saddle by Lukyashko S.I. is licensed under a Creative Commons Attribution 4.0 International License 

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