Researcher of R&D Department, Research Institute of Mitoengineering, Lomonosov Moscow State University

Leninskie gory St., 1, 119991 Moscow, Russian Federation

 

Candidate of Sciences (Chemistry), Associate Professor, Department of Bioorganic Chemistry, Lomonosov Moscow State University

Leninskie gory St., 1, 119991 Moscow, Russian Federation

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Abstract. The study is devoted to 8-oxo-2'-deoxyguanosine (8-oxo-dG), which is used as a biomarker of oxidative damage to DNA and its associated diseases. The study is based on the hypothesis put forward by the authors about the ability of 8-oxo-dG, which is the main product of DNA oxidation, to act as a signal molecule that activates cell resistance to nonspecific stress and DNA repair. In addition to studying the molecular mechanisms of the action of 8-oxo-dG, the authors have carried out an investigation of the effects that they caused on the organism level.

 

Key words: 8-oxo-dG, biomarker, signal molecule, pharmaceutical agent.