Marmiy N.V., Esipov D.S. 8-Oxo-2'-Deoxyguanosine - Biomarker, Signal Molecule, Potential Pharmaceutical Agent

DOI: https://doi.org/10.15688/jvolsu11.2018.1.9

 
Natalya V. Marmiy
Researcher of R&D Department, Research Institute of Mitoengineering, Lomonosov Moscow State University
Leninskie gory St., 1, 119991 Moscow, Russian Federation
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Dmitriy S. Esipov
Candidate of Sciences (Chemistry), Associate Professor, Department of Bioorganic Chemistry, Lomonosov Moscow State University
Leninskie gory St., 1, 119991 Moscow, Russian Federation
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Abstract. The study is devoted to 8-oxo-2'-deoxyguanosine (8-oxo-dG), which is used as a biomarker of oxidative damage to DNA and its associated diseases. The study is based on the hypothesis put forward by the authors about the ability of 8-oxo-dG, which is the main product of DNA oxidation, to act as a signal molecule that activates cell resistance to nonspecific stress and DNA repair. In addition to studying the molecular mechanisms of the action of 8-oxo-dG, the authors have carried out an investigation of the effects that they caused on the organism level.
 
Key words: 8-oxo-dG, biomarker, signal molecule, pharmaceutical agent.
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