Vasilyev P.M., Kosolapov V.A., Spasov A.A., Yanalieva L.R. Polyfunctional Multitarget Drugs as a Basis of Pharmacology of the 21st Century

DOI: https://doi.org/10.15688/jvolsu11.2018.1.6

Pavel M. Vasilyev
Doctor of Sciences (Biology), Professor, Department of Pharmacology and Bioinformatics, Senior Researcher of Research Institute of Pharmacology, Volgograd State Medical University
Pavshikh Bortsov Sq., 1, 400131 Volgograd, Russian Federation
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Vadim A. Kosolapov
Doctor of Sciences (Medicine), Professor, Department of Pharmacology and Bioinformatics, Volgograd State Medical University
Pavshikh Bortsov Sq., 1, 400131 Volgograd, Russian Federation
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Aleksandr A. Spasov
Academician of the Russian Academy of Sciences, Honoured Scientist of the Russian Federation, Doctor of Sciences (Medicine), Professor, Head of Department of Pharmacology and Bioinformatics, Volgograd State Medical University
Pavshikh Bortsov Sq., 1, 400131 Volgograd, Russian Federation
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Laura R. Yanalieva
Assistant, Department of Pharmacology and Bioinformatics, Volgograd State Medical University
Pavshikh Bortsov Sq., 1, 400131 Volgograd, Russian Federation
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Abstract. Due to the fact that all diseases began to be considered as multifactorial, the main direction of pharmacology in the 21st century is the design of multitarget ligands. The relevance of this approach is confirmed by the authors’ research in the field of analysis of the  
spectrum of affinity for nine ion channels of the heart for three antiarrhythmic drugs, as well as the results of initiatory research into the search for fundamentally new multifunctional multitarget inhibitors of glycation end-product receptors.
 
Key words: network pharmacology, drugs, multitarget ligands.
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Polyfunctional Multitarget Drugs as a Basis of Pharmacology of the 21st Century by Vasilyev P.M., Kosolapov V.A., Spasov A.A., Yanalieva L.R. is licensed under a Creative Commons Attribution 4.0 International License.
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