Zaitsev V.G., Litus E.A., Zhdanova A.V. Different changes of the serum albumin cobalt-binding capacity induced by various oxidants
Zaitsev Valery Gennadyevich
Candidate of Biological Sciences, Associate Professor, Department of Bioengineering and Bioinformatics, Volgograd State University
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Litus Ekaterina Andreevna
Assistant, Department of Basic and Clinical Biochemistry, Volgograd State Medical University
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Zhdanova Anna Vitalyevna
Specialist of Clinical Laboratory, 1st Clinic, Volgograd State Medical University
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Summary: Impact of in vitro oxidative modification of the bovine serum albumin (BSA) on its cobaltbinding capacity (CoBC) was studied. We found various oxidants differently changed CoBC of BSA. The Fenton’s reagents producing hydroxyl radical decreased or not alter CoBC of BSA depending on composition of ones. In contrast, treatment of BSA by hypochlorous acid, a physiological oxidant, elevated CoBC of this protein. Probable causes of different effects produced by various oxidants is discussed.
Key words: serum albumin, proteins, oxidative modification, Fenton’s reagent, hydroxyl radical, hypochlorous acid, cobalt.
Different changes of the serum albumin cobalt-binding capacity induced by various oxidants by Zaitsev V.G., Litus E.A., Zhdanova A.V. is licensed under a Creative Commons Attribution 4.0 International License.
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